Trazodone benadryl

Combining medications, such as Benadryl and Trazodone, should be done with caution and under the guidance of a healthcare professional. It is essential to consider any potential risks or side effects when combining these medications. Stay tuned to learn more about the potential interactions between Benadryl and Trazodone and how they can affect ...

Trazodone benadryl. The withdrawal period can vary in length from one week to four weeks. Most often, it is brief. Symptoms that occur as a result of withdrawal from trazodone are typically mild compared to other withdrawal syndromes (e.g., withdrawal from alcohol, pain medications, benzodiazepines, etc.), and the symptoms appear to mimic a mild case of influenza.

The answer is yes. Trazodone and Benadryl can be given together to your dog, but only under the supervision of a veterinarian. Trazodone is an antidepressant that is used in humans to treat anxiety, depression, and insomnia while Benadryl treats allergies and itching caused by pets or food items. This means that if your dog has been …

Constipation. continuing ringing or buzzing or other unexplained noise in the ears. diarrhea. hearing loss. muscle aches or pains. weight loss. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects.Trazodone is a prescription medication approved for use by the Food and Drug Administration (FDA) as an antidepressant.. This medicine works in multiple ways in your body. One of its actions is to ...Trazodone is safe to take for a long time. There do not seem to be any lasting harmful effects from taking it for many months, or even years. Some people need to take trazodone long term to treat depression or anxiety that keeps coming back. If you need it and do not get side effects, there's no reason to worry about taking trazodone for a long ...Very low sodium levels can be life-threatening, leading to seizures, passing out, trouble breathing, or death. If you are 65 or older, use this medicine (trazodone tablets) with care. You could have more side effects. Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding.This topic last updated: Apr 29, 2024. Insomnia is one of the most common symptoms for which adults seek medical advice. While pharmacotherapy should not be …unusual bruising or bleeding. nosebleeds. small red or purple dots on the skin. erection lasting more than 6 hours. headache. problems with thinking, concentration, or memory. weakness. problems with coordination. Trazodone can cause painful, long lasting erections in males.Trazodone differs from Ambien, Sonata, Lunesta and other "sleeping pill" medications in a few ways: Both Ambien and Lunesta are classified by the FDA as controlled substances because they have the potential for misuse and abuse, including dependence or addiction. Because trazodone is not a controlled substance, physicians aren’t limited in ...Trazodone is a triazolopyridine derivative that belongs to the class of serotonin receptor antagonists and reuptake inhibitors (SARIs). The drug is approved and marketed in several countries worldwide for the treatment of major depressive disorder (MDD) in adult patients. In clinical studies, trazodone has demonstrated comparable …

Trazodone is a widely used but little-known drug prescribed off-label to treat insomnia, Consumer Reports notes. ... doesn’t recommend them. In addition, drugs such as diphenhydramine can cause ...Trazodone significantly impairs memory, verbal learning and eyesight. I've taken this medication for 20 years and am now legally blind without a prescription. Trazodone gave me chronic fatigue syndrome, orthostatic intolerance, arrhythmia and cerebral ischemia. ... Before that I was on klonopin, benadryl, tylenol pm, ambien, etc, none of which ...Studies confirm that Trazodone can affect your sexual health. It’s also sometimes used to treat erectile dysfunction: when you can’t get or keep an erection strong enough for sex. Here are common sexual side effects you might experience when using Trazodone: Increased or Decreased Libido. Impaired Ejaculation.Drug Images. What is trazodone oral tablet? Trazodone is a generic prescription drug. It’s FDA-approved to treat major depressive disorder (MDD) in adults. MDD is also called depression. For...Benadryl (Diphenhydramine) received an overall rating of 7 out of 10 stars from 221 reviews. See what others have said about Benadryl (Diphenhydramine), including the effectiveness...Trazodone and doxylamine succinate can work well together, but only for two, maybe three nights max. You'll need to switch to another method or medicine for two or three nights to allow these two meds to clear out of your system. I take 300mg of trazodone and 50mg diphen pretty I every night. 🤦🏼‍♀️.2. Diphenhydramine (Benadryl) Diphenhydramine is an antihistamine that can help treat allergies, itching, and cold symptoms. Diphenhydramine may show up as a false positive for some opioids. But it’s not clear what dose of diphenhydramine would cause a false positive. Typical doses of diphenhydramine may not cause a false positive.Apr 7, 2022 ... Antihistamines: Understanding Your OTC Options. Last Updated April 2022 | This ... Diphenhydramine (three brand names: Benadryl, Nytol, Sominex) ...

Drug-Drug Interactions. See also PRECAUTIONS, Drug Interactions. In vitro drug metabolism studies reveal that trazodone is a substrate of the cytochrome P450 3A4 (CYP3A4) enzyme and trazodone metabolism can be inhibited by the CYP3A4 inhibitors ketoconazole, ritonavir, and indinavir. The effect of short-term administration of ritonavir …The serotonin effects of trazodone occur within half an hour of taking a dose, so side effects such as drowsiness, dry mouth, dizziness, trouble sleeping, nausea, urinary incontinence, blurred vision, genital numbing, and similar side effects are sometimes experienced early or even after the first dose. Other side effects, such as sexual ...Reads 118. Yes, dogs can have trazodone and benadryl together. The two medications can be used to help manage anxiety and itching, respectively. When used together, the doses of each medication may need to be adjusted to avoid potential side effects. Some common side effects of trazodone include sedation, dizziness, and dry …Benadryl (Diphenhydramine) is commonly recognized as an antihistamine primarily used to treat allergies. On the other paw, Gabapentin, initially designed for humans to manage seizures, has found its place in the veterinary world to help manage pain and anxiety in dogs. Combining these two might sound like you’re prepping a cocktail, but …Pharmacodynamics. Trazodone treats depressed mood and other depression-related symptoms and shows benefit in the treatment of insomnia due to its sedating effects. 20 It is known to prolong the cardiac QT-interval. 21 Memory, alertness, and cognition may be decreased by trazodone, especially in elderly patients due to its central nervous system depressant effects. 9Trazodone is an antidepressant and sedative that has been used to treat depression and symptoms of insomnia (unable to sleep or having poor sleep). It is often used in combination with other medications used to treat depression. Some brand names for trazodone include Desyrel®, Oleptro®, and Trazorel®.

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2. Diphenhydramine (Benadryl) Diphenhydramine is an antihistamine that can help treat allergies, itching, and cold symptoms. Diphenhydramine may show up as a false positive for some opioids. But it’s not clear what dose of diphenhydramine would cause a false positive. Typical doses of diphenhydramine may not cause a false positive.Access up-to-date medical information for less than $1 a week. Purchase a subscription I’m already a subscriber. Browse sample topics. Find information on Trazodone (Desyrel) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.Robot astronauts will be able to work in space much more efficiently than people -- Learn how they will work! Advertisement It's hard to imagine a more dramatic undertaking than sp...diphenhydrAMINE traZODone. Applies to: Benadryl Allergy (diphenhydramine) and trazodone. Using diphenhydrAMINE together with traZODone may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination.Aug 9, 2022 · The serotonin effects of trazodone occur within half an hour of taking a dose, so side effects such as drowsiness, dry mouth, dizziness, trouble sleeping, nausea, urinary incontinence, blurred vision, genital numbing, and similar side effects are sometimes experienced early or even after the first dose. Other side effects, such as sexual ... Jul 10, 2022 · Trazodone is a medication used in the management and treatment of major depressive disorder. It is in the serotonin-antagonist-and-reuptake-inhibitor class of medications. This activity reviews the indications, action, and contraindications for trazodone as a valuable agent in managing major depression. This activity will highlight the mechanism of actions, adverse effects, and other key ...

Your 401k represents one part of a portfolio that might also include an IRA, Social Security payments, pension checks and personal savings. You spend your life building up the mone...Reads 112. Yes, trazodone and benadryl can be taken together for dogs. They may be used to treat different conditions, but they work well together to provide relief for your dog. Benadryl is an antihistamine that can be used to treat allergies, while trazodone is an antidepressant that can be used to treat anxiety.Mar 27, 2018 ... ... antihistamines. Summary. Although there are no drug interactions between trazodone and cetirizine, caution may be needed due to an increased ...Trazodone is a medication used in the management and treatment of major depressive disorder. It is in the serotonin-antagonist-and-reuptake-inhibitor class of medications. This activity reviews the indications, action, and contraindications for trazodone as a valuable agent in managing major depress …Trazodone is an antidepressant medication. It’s FDA approved to treat depression, but it’s more often used off-label for insomnia. When taken 30 minutes before bedtime, a low dose of trazodone (between 25 mg and 100 mg) may be effective for sleep problems. Trazodone is considered safe to take for short-term insomnia symptoms.Trazodone is a serotonin modulator, i.e. it acts to normalize serotonin levels within the brain. Serotonin is a neurotransmitter that promotes a sense of well-being. By normalizing the levels of serotonin, trazodone provides mild sedation and relieves anxiety. The drug has been around since the 1980s but vets started using it in the last decade ...Benadryl is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is a common side effect... more. Prescription only. Trazodone is mostly used for its sleep-inducing effects (an off-label indication) rather than as an antidepressant.Computers have (happily) advanced to the point where we spend more time getting work done on them than we do fixing them, you still occasionally need a solid diagnostic tool. What ...FDA APPROVES NANOBIOTIX'S FIRST IMMUNO-ONCOLOGY TRIAL:A PHASE I/II STUDY OF NBTXR3 ACTIVATED BY RADIATION THERAPY (SABR) FOR PATIENTS WITH NON-SM... FDA APPROVES NANOBIOTIX'S FIRST...In addition, trazodone is sometimes prescribed off-label for difficulty sleeping (insomnia). This medication is taken by mouth, typically once or a few times a day, depending on your condition. Common side effects of this medication include sleepiness, dry mouth, and dizziness. Brand name Desyrel has been discontinued.

Trazodone Interactions. There are 647 drugs known to interact with trazodone, along with 8 disease interactions, and 1 alcohol/food interaction.Of the total drug interactions, 136 are major, 496 are moderate, and 15 are minor.

Dosage. Take as directed. Warnings. Interactions. Important considerations. Alternatives. Trazodone is a generic drug that doctors may prescribe to treat depression. …Specializes in Neurology. You are on a path toward escalating sleep medication which is destined eventually to make things worse. Best not to combine if possible, and perhaps titrate the Trazadone initially without the Benadryl. Sleep hygiene program is far better, and if you can plan on stopping medication in future would provide …For trazodone hydrochloride. Withdrawal effects may occur within 5 days of stopping treatment with antidepressant drugs; they are usually mild and self-limiting, but in some cases may be severe. The risk of withdrawal symptoms is increased if the antidepressant is stopped suddenly after regular administration for 8 weeks or more.Mixing trazodone with herbal remedies and supplements. Do not take St John's wort, the herbal remedy for depression, while you're being treated with trazodone as this will increase your risk of side effects. There's not enough information to say that other herbal remedies and supplements are safe to take with trazodone.- Diagnostic criteria for chronic insomnia disorder (ICSD-3-TR) - Nonbenzodiazepine BZRAs in the management of insomnia in adults - Other drugs for the management of insomnia in adults - Safe medication prescribing practices for insomnia - US scheds controlled drugs - Benzodiazepines in the management of insomnia in adults - …Trazodone is a serotonin receptor antagonist and reuptake inhibitor used extensively as an anxiolytic in human and small animal veterinary medicine. The aims of this study were to determine the pharmacokinetics of oral trazodone in experimental horses and to evaluate the effect of oral trazodone in clinical horses.Trazodone. Brand name: Molipaxin. Find out how trazodone treats depression and anxiety and how to take it. About trazodone. Who can and cannot take it. How and when to take it. Side effects. Pregnancy, breastfeeding and fertility. Taking trazodone with other medicines and herbal supplements.About trazodone. Trazodone is an antidepressant medicine. It's used to treat depression, anxiety, or a combination of depression and anxiety. Trazodone works by increasing your levels of serotonin and noradrenaline so you feel better. It can help if you're having problems like low mood, not sleeping ( insomnia) and poor concentration.View trazodone alcohol/food interactions (1) View trazodone disease interactions (8) Most frequently checked interactions. View interaction reports for trazodone and the medicines listed below. Major; Moderate; Minor; Unknown; Abilify (aripiprazole) Adderall (amphetamine / dextroamphetamine) Ambien (zolpidem) Ativan (lorazepam) Benadryl ...

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COVID psychosis is a rare mental health condition impacting a small number of people globally who had COVID-19. Researchers know very little about this condition, but the symptoms ...Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. phenytoin. trazodone increases levels of phenytoin by unspecified interaction mechanism.Answers. MA. masso 1 July 2019. Taking both medications has a moderate interaction, meaning: Moderately clinically significant. Usually avoid combinations; use it only under …A common side effect of taking trazodone is feeling sleepy or tired. 3 This side effect is what highlighted the potential for trazodone to be used as a sleep aid. When used to help people sleep, the dosage of trazodone prescribed differs from other use cases. For depression, it’s usually given at a starting dose of 150mg/day and for anxiety ...Take this insta-inspiration from Instagram for your next outdoor family adventure. THERE HAVE been many things said about social media, good and bad. One major benefit of a platfor...Many women with depression or anxiety have difficulty falling asleep or they wake early and are unable to return to sleep. Treating the underlying disorder may improve sleep quality. ( More information on the treatment of depression and anxiety during pregnancy can be found here.) Typically antidepressants, including fluoxetine (Prozac) and the ...Jan 15, 2023 · Trazodone oral tablet is prescribed for depression. Learn about side effects, use for sleep, dosage, and more. Health Conditions. ... (Benadryl) — Your doctor or pharmacist can provide you with ... I have insomnia - both trouble falling asleep and staying asleep. i've tried cbt, and i've tried trazodone, remeron, (mirtazapine) diphenhydramine and seroquil. none have been romotely effective. is there a drug that might actually help? 6 doctors weighed in across 2 answers. ….

Trazodone may also be used to treat other conditions such as problems sleeping, anxiety, and panic attacks. Buy Trazodone Tablets Online - Free Worldwide Shipping Trazodone is an oral state of mind elevator considered depression, anxiety (when it's a sign of misery), …Since Trazodone is a sedative, it provides a calming and relaxing effect, which may encourage abuse. People who abuse Trazodone rarely abuse it alone, and often take it with other drugs like alcohol, methamphetamine, and ecstasy (Molly), which increases the risk of overdose and harmful side effects.Descriptions. Trazodone is used to treat depression. It is thought to work by increasing the activity of serotonin in the brain. Trazodone is an antidepressant. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms: Tablet.Stock speculators raked an average of $175 million per day this month betting against Tesla. It’s mostly been a tough year for those betting against Tesla. The company’s stock pric...Trazodone is an antidepressant medication that can help treat major depressive disorder. Your doctor may also prescribe it off-label for anxiety. it isn’t habit-forming, but can cause these side ... Acetaminophen (paracetamol) and diphenhydramine: Drug information; Acetaminophen (paracetamol) and phenylephrine: Drug information; Acetaminophen (paracetamol) and phenyltoloxamine: Drug information; Acetaminophen (paracetamol) and tramadol: Drug information; Acetaminophen (paracetamol), aspirin, and caffeine: Drug information There are no reported withdrawal symptoms for Benadryl if taken as directed. Benadryl is a brand name for the antihistamine diphenhydramine, which is not considered to be an addict...Trazodone cannot be taken with Nyquil/ Benadryl/ Zoloft/ Cymbalta/ valium/ paxil/ flexeril/ Xanax. Trazodone can be taken with melatonin . Please consult your doctor for any … Trazodone benadryl, Apr 19, 2020 ... Stop taking antihistamines that make you drowsy: Alternatives to Diphenhydramine (Benadryl). ... trazodone 50 mg uses dosage and side effects., The serotonin effects of trazodone occur within half an hour of taking a dose, so side effects such as drowsiness, dry mouth, dizziness, trouble sleeping, nausea, urinary incontinence, blurred vision, genital numbing, and similar side effects are sometimes experienced early or even after the first dose. Other side effects, such as sexual ..., Trazodone is an antidepressant medication. It’s FDA approved to treat depression, but it’s more often used off-label for insomnia. When taken 30 minutes before bedtime, a low dose of trazodone (between 25 mg and 100 mg) may be effective for sleep problems. Trazodone is considered safe to take for short-term insomnia symptoms., Applies to: Benadryl (diphenhydramine) and trazodone. Using diphenhydrAMINE together with traZODone may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination., Trazodone is an antidepressant and sedative that has been used to treat depression and symptoms of insomnia (unable to sleep or having poor sleep). It is often used in combination with other medications used to treat depression. Some brand names for trazodone include Desyrel®, Oleptro®, and Trazorel®. Sometimes when people find out they are ..., Trazodone differs from Ambien, Sonata, Lunesta and other "sleeping pill" medications in a few ways: Both Ambien and Lunesta are classified by the FDA as controlled substances because they have the potential for misuse and abuse, including dependence or addiction. Because trazodone is not a controlled substance, physicians aren’t limited in ..., Trazodone hydrochloride tablets, USP are available as follows: Trazodone hydrochloride tablets, USP 50 mg are white, round, convex, bisected, film-coated tablets, debossed 'S/14' on one side and having break-line on other side. Bottles of 100 CRC NDC 57664-014-72. Bottles of 500 NCRC NDC 57664-014-74. Bottles of 1000 NCRC NDC …, Trazodone is only available as a generic drug; all brands have been discontinued. Generic trazodone is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. Get trazodone for as low as $4.85, which is 71% off the average retail price of $16.67 for the most common version, by using a GoodRx coupon. , unusual bruising or bleeding. nosebleeds. small red or purple dots on the skin. erection lasting more than 6 hours. headache. problems with thinking, concentration, or memory. weakness. problems with coordination. Trazodone can cause painful, long lasting erections in males. , Trazodone, often spotlighted for its role in the sleep-aid drama, is actually an antidepressant that doubles as a knight in shining armor for those battling insomnia. On the other side, we have Benadryl, a widely known antihistamine that combats allergies but also moonlights as a sleep aid due to its sedative properties., Trazodone has alpha-1 adrenergic blocking activity and may cause hypotension (including orthostatic hypotension) in approximately 5% of patients. Therapy with trazodone should be administered cautiously in patients with hypotension or conditions that could be exacerbated by hypotension, such as a history of myocardial infarction, angina, or ..., Routine use of OTC antihistamines such as diphenhydramine (Benadryl) and doxylamine (Unisom) ... Trazodone is the most commonly prescribed sleep aid, but there is insufficient evidence to support ..., Trazodone (and metabolite) [83] (nM). The smaller the value, the more strongly the drug binds to the site. Trazodone is a mixed agonist and antagonist of various serotonin receptors, antagonist of adrenergic receptors, weak histamine H 1 receptor antagonist, and weak serotonin reuptake inhibitor., As more toll roads go cashless, rental car agencies are happy to cash in by charging excessive administrative fees. Here's how to avoid these absurd charges. "To leave the airport,..., Trazodone doses between 25 and 150 mg do not achieve antidepressant activity but have hypnotic activity through antagonism of 5-HT 2a, H 1, and α1 receptors.Estimates of brain receptor occupancy based on a pharmacokinetic model support the multimodal activity of trazodone, which may contribute to the rapid onset of its …, Trazodone is an atypical anti-depressant drug. Anti-depressant drugs correct the chemical imbalances in the brain that cause mood and behavior disorders. Trazodone is part of a newer class of atypical anti-depressants, which affect both norepinephrine and serotonin. It is available in 50-, 100-, 150- and 300-mg tablets, to be taken orally., Desyrel side effects. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.. Stop taking Desyrel and call your doctor at once if you have a penis erection that is painful or lasts 6 hours or longer., Dose of trazodone or quetiapine (mg per night), psychiatric diagnosis at discharge, and number of concomitant sedating medications taken at bedtime were also collected for each patient. Table 1. Daily Data Collection Regimen ... Drug names: diphenhydramine (Benadryl and others), eszopiclone (Lunesta), quetiapine (Seroquel), …, Benadryl is an antihistamine that can be used to treat allergic reactions, relieve motion sickness, as a sleep aid, and relieve some symptoms of Parkinson's disease. Sedation is …, Jul 10, 2022 · Trazodone is a medication used in the management and treatment of major depressive disorder. It is in the serotonin-antagonist-and-reuptake-inhibitor class of medications. This activity reviews the indications, action, and contraindications for trazodone as a valuable agent in managing major depression. This activity will highlight the mechanism of actions, adverse effects, and other key ... , Trazodone is associated with a number of side effects. Relatively mild side effects include nausea, vomiting, changes in appetite, weight loss or weight gain, muscle pain, dry mouth, dizziness, blurred vision, itching, skin rashes, and constipation. Some patients experience light to moderate impairment after taking trazodone., Access up-to-date medical information for less than $1 a week. Purchase a subscription I’m already a subscriber. Browse sample topics. Find information on Trazodone (Desyrel) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF., Trazodone and Benadryl. Using Benadryl and trazodone together can result in increased side effects. These can include profound dizziness, confusion, difficulty concentrating and especially drowsiness. In certain populations, like the elderly, this combination can impair thinking, judgment and motor coordination., Access up-to-date medical information for less than $1 a week. Purchase a subscription I’m already a subscriber. Browse sample topics. Find information on Trazodone (Desyrel) in Davis’s Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF., SIDE EFFECTS: See also the Warning section. Nausea, vomiting, diarrhea, drowsiness, dizziness, tiredness, blurred vision, changes in weight, headache, muscle ache/ pain, dry mouth, bad taste in the mouth, stuffy nose, constipation, or change in sexual interest/ability may occur. If any of these effects persist or worsen, tell your doctor or ..., Trazodone is a medication used in the management and treatment of major depressive disorder. It is in the serotonin-antagonist-and-reuptake-inhibitor class of medications. This activity reviews the indications, action, and contraindications for trazodone as a valuable agent in managing major depress …, Trazodone is an FDA-approved antidepressant for treating major depressive disorders. [1] The drug can be used as a component of combination therapy with other drugs or psychotherapies or as monotherapy for treating depression. [2] Non-FDA-Approved Uses. Trazodone is used off-label for patients with insomnia., Trazodone is an anti-anxiety medication often prescribed by vets to ease short-term anxiety in dogs and cats. It can help your dog to cope with stress and recover after surgery or other difficult events. But it doesn’t just improve their well-being. It can also improve your peace of mind., As more toll roads go cashless, rental car agencies are happy to cash in by charging excessive administrative fees. Here's how to avoid these absurd charges. "To leave the airport,..., You can take Claritin and Benadryl together, but the effect of both drugs overlap, according to BJC HealthCare. Both Claritin and Benadryl are antihistamines, which means that taki..., Jan 15, 2023 · Trazodone oral tablet is prescribed for depression. Learn about side effects, use for sleep, dosage, and more. Health Conditions. ... (Benadryl) — Your doctor or pharmacist can provide you with ... , Benadryl has an average rating of 7.3 out of 10 from a total of 78 ratings on Drugs.com. 65% of reviewers reported a positive effect, while 18% reported a negative effect. Trazodone has an average rating of 6.3 out of 10 from a total of 1410 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 31% reported a negative …, 1. Introduction. Trazodone is a medication that possesses antidepressant, anxiolytic, and hypnotic properties. Its mechanism of action includes blockade of serotonin type 2 receptors, weak inhibition of serotonin reuptake, blockade of histamine 1 receptors, and blockade of alpha-1-adrenergic receptors [].